Only the parts of Zowe that involve Java code are ZIIP enabled. The API Mediation Layer composed of the API Gateway, Discovery and Catalog servers along with any Java-based services that work with them such as the Jobs and Datasets servers are ZIIP enabled. Also, the CLI and VSCode Explorer make large use of z/OSMF, which is Java so they are ZIIP enabled as well. More details on portions of Zowe which are Java (ZIIP) enabled can be found here.
This leaves C and NodeJS code which are not ZIIP enabled, BUT, we have a tech preview available currently that allows execution of Java as well as NodeJS code, on Linux or zLinux via Docker. With the tech preview, only the C code remains on z/OS, which is not ZIIP enabled.